Figure 7
Effects of Ani/Neo combination on levels of H2O2, MPO, total NO, TNFα, IL-6, and IL-10 in decompressed muscle in WT and α7nAChR KO mice CS model.
WT and α7nAChR KO mice were subjected to hind-limbs compression for 4 h, and then injected with vehicle; or Ani/Neo combination (28 mg/kg and 56 μg/kg, i.p.) at 30 min before decompression. Compressed muscle was collected at 6 h after decompression. Levels of H2O2, MPO, total NO, TNFα, IL-6, and IL-10 in compressed muscle were measured respectively. n = 6 per group. Veh, vehicle; MPO, myeloperoxidase; WT, wild-type; KO, knockout; Ani, anisodamine; Neo, neostigmine; *P < 0.05 vs. Sham, **P < 0.01 vs. Sham, #P < 0.05 vs. CS+Veh, ##P < 0.01 vs. CS+Veh.
