Table 1 Effects of Ani and Neo on 24 h survival rate in rat CS model.

From: Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling

Ani

Dose (mg/kg)

Neo

0

5

10

20

Dose (μg/kg)

0

13.3

33.3

46.7

60.0**

5

20.0

53.3*

60.0**

60.0**

10

33.3

60.0**

66.7**

60.0**

20

40.0

66.7**

80.0***

66.7**

40

46.7**

60.0**

66.7**

86.7***

  1. Rats were subjected to hind-limbs compression for 5 h, followed by treatment with vehicle, Ani (5, 10, and 20 mg/kg, i.p.), Neo (5, 10, 20 and 40 μg/kg, i.p.), or combination of Ani and Neo at 30 min before decompression. Survival rates were monitored for the ensuing 24 h. n = 15 per group. *P < 0.05 vs. vehicle, **P < 0.01 vs. vehicle, ***P < 0.001 vs. vehicle. Ani, anisodamine; Neo, neostigmine.
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