Table 2 Effects of combined Ani/Neo at 500:1 ratio on serum CK, CK-MB, BUN, Cr and K+ in rat CS model.

From: Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling

Group

CK (U/mL)

CK-MB (U/mL)

BUN (μmol/L)

Cr (μmol/L)

K+ (mmol/L)

Sham

0.7 ± 0.2

1.2 ± 0.5

8.0 ± 1.1

22.2 ± 2.6

6.5 ± 0.45

Vehicle

57.2 ± 15.2**

3.2 ± 1.2*

29.7 ± 2.0**

108 ± 20.5**

11.3 ± 0.7**

Ani(5 mg/kg)+ Neo(10 μg/kg)

44.3 ± 1.9##

2.5 ± 0.4#

28.2 ± 1.8#

90.2 ± 16.2#

10.1 ± 0.5#

Ani(10 mg/kg)+ Neo(20 μg/kg)

38.7 ± 6.9##

2.2 ± 0.3##

27.5 ± 2.3##

76.3 ± 21.9##

9.3 ± 0.4##

Ani(20 mg/kg)+ Neo(20 μg/kg)

36.1 ± 4.9##

2.6 ± 0.3##

26.4 ± 2.6##

59.7 ± 13.1##

9.1 ± 0.5##

  1. Rats were subjected to hind-limbs compression for 5 h, followed by treatment with vehicle or three different doses of Ani/Neo combination with a ratio of 500:1 at 30 min before decompression. Blood samples were collected at 6 h after decompression. Levels of CK, CK-MB, BUN, Cr and K+ in serum were measured. n = 20 per group. *P < 0.05 vs. Sham, **P < 0.01 vs. Sham, #P < 0.05 vs. vehicle, ##P < 0.01 vs. vehicle. Ani, anisodamine; Neo, neostigmine.
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