Table 3 Effects of combined Ani and Neo at 500:1 ratio on serum CK, CK-MB, BUN, Cr and K+ levels rabbit CS model.

From: Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling

Group

CK (U/mL)

CK-MB (U/mL)

BUN (μmol/L)

Cr (μmol/L)

K+ (mmol/L)

Sham

2.3 ± 1.93

0.41 ± 0.15

19.1 ± 1.83

101 ± 17.6

5.38 ± 0.58

Vehicle

128.4 ± 15**

2.97 ± 0.49**

23.9 ± 2.31*

133 ± 29.9*

12.0 ± 1.2**

Ani(2.5 mg/kg)+ Neo(5 μg/kg)

124.6 ± 16.7

2.74 ± 0.53

23.1 ± 2.31

116 ± 31.9

10.5 ± 1.99#

Ani(5 mg/kg)+ Neo(10 μg/kg)

93.2 ± 17.1##

2.62 ± 0.54#

22.8 ± 2.06

111 ± 19.1

10.4 ± 1.27#

Ani(10 mg/kg)+ Neo(20 μg/kg)

91.5 ± 9.55##

2.47 ± 0.25#

19.9 ± 2.96##

98.9 ± 22.7#

9.22 ± 1.12##

  1. Rabbits were subjected to hind-limbs compression for 6 h, followed by treatment with vehicle or Ani/Neo combination with a ratio of 500:1 at 30 min before decompression. Blood samples were collected at 6 h after decompression. Levels of CK, CK-MB, BUN, Cr and K+ in serum were measured. n = 8 per group. *P < 0.05 vs. Sham, **P < 0.01 vs. Sham, #P < 0.05 vs. vehicle, ##P < 0.01 vs. vehicle. Ani, anisodamine; Neo, neostigmine.
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