Table 3 Calculated IC50 values from both human and rat liver mitochondria in the presence of ER-000444793 and CsA.

From: Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

 

IC50 Calcium Retention

ER-000444793

CsA

IC 50 (M)

CI (95%)

IC 50 (M)

CI (95%)

Rat

1.20E-06

9.5E-07 to 1.4E-06

3.40E-08

2.8E-08 to 4.2E-08

Human

2.00E-06

1.5E-06 to 2.7E-06

1.20E-07

9.3E-08 to 1.4E-07

  1. Data presented as mean IC50, calculated from three independent experiments and 95% confidence interval (CI).
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