Figure 4 | Scientific Reports

Figure 4

From: Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia

Figure 4

Visualization of allodynia in peripheral nerve injury model mice with fMRI.

(A) BOLD signals in intact mice (green) were only observed in the contralateral S1 hindpaw region following 2000 Hz electrical stimulation. At postoperative day 7, an additional BOLD signal (magenta) was detected in the ACA, S1, and thalamus of the same animals. (B) For the quantitative assessment for allodynia, the signal change (%) was calculated by subtracting the MR signal in the ACA, S1, and thalamus, before and after peripheral nerve injury, from sham-operated mice. Significantly higher BOLD signals were observed in the ACA and thalamus after peripheral nerve injury. There were no significant differences between sham and SNL groups. Green, intact (preoperation); magenta, peripheral nerve injury; blue, sham-operated, MR signal threshold P < 0.05 voxel-wise FWE corrected, 2-sample t-test (*p < 0.05, **p < 0.005).

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