Table 4 Comparing interested outcomes risks between patients with SLE with and without vaccination stratified by age.

From: Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study

Age Group (years)

Nonvaccine cohort

Vaccine cohort

IRR

Adjusted HRb

(95% CI)

Variables

n (%)

Incidencea

n (%)

Incidencea

Total hospitalization

 18–65

1786

(22.11)

25.71

296

(21.07)

23.95

0.93

0.87

(0.77–0.98)*

 ≥65

108

(38.03)

53.67

109

(30.28)

37.09

0.69

0.70

(0.54–0.92)**

Hospitalization for Pneumonia

 18–65

147

(1.82)

1.85

27

(1.92)

1.95

1.05

0.88

(0.47–1.33)

 ≥65

27

(9.51)

10.99

20

(5.56)

5.84

0.53

0.46

(0.25–0.83)*

Hospitalization for septicemia, bacteremia, or viremia

 18–65

137

(1.70)

1.72

14

(1.00)

1.01

0.59

0.49

(0.28–0.86)*

  ≥ 65

24

(8.45)

9.62

19

(5.28)

5.50

0.57

0.47

(0.25–0.87)*

Hospitalization for heart disease

 18–65

434

(5.37)

5.59

97

(6.90)

7.20

1.02

1.02

(0.82–1.28)

 ≥65

46

(16.20)

19.37

53

(14.72)

16.26

0.84

0.76

(0.50–1.13)

ICU admission

 18–65

171

(2.12)

2.15

23

(1.64)

1.66

0.77

0.63

(0.40–0.98)*

 ≥65

31

(10.91)

12.43

23

(6.39)

6.72

0.54

0.48

(0.28–0.83)**

In-hospital dialysis

 18–65

66

(0.82)

0.83

5

(0.36)

0.36

0.43

0.40

(0.20–0.81)*

 ≥65

7

(2.46)

2.74

5

(1.39)

1.43

0.52

0.47

(0.41–1.55)

Death

 18–65

97

(1.20)

1.21

11

(0.78)

0.79

0.65

0.52

(0.28–0.97)*

 ≥65

40

(14.08)

15.57

23

(6.39)

6.58

0.42

0.36

(0.21–0.71)***

  1. Abbreviations: IRR, Incidence rate ratio; HR, Hazard Ratio; CI, Confidence Interval; ICU, Intensive Care Unit.
  2. *P value for HR < 0.05, **P value for HR < 0.01, ***P value for HR < 0.001.
  3. aIncidence rate per 100 person-year.
  4. bHR were adjusted for age, sex, and comorbidities.