Figure 4
From: Long intergenic non-coding RNA expression signature in human breast cancer
Specific expression of lincRNAs in breast cancer subtypes.
(A) Heatmap of three lincRNAs specifically over-expressed in ER+ breast cancer. Red and green represent 664 ER+ and 196 ER- cancer samples from TCGA, respectively. Black bar denotes 85 adjacent normal tissues. Distribution of DNA binding by ERĪ± in three lincRNA genes, (B) GATA3-AS1 (Ensemble ID ENSG00000197308), (C) RP11-279F6 (Ensemble ID ENSG00000245750) and (D) AC017048 (Ensemble ID ENSG00000224577). The gray bars represent the DNA binding enrichment for the ERĪ± in the MCF-7 cells. The track in the top for each lincRNA is the chromatin states from the chromHMM algorithm in the HMEC cell line. Chromatin states with bright red and light red, orange and yellow, blue, green and grey represent active promoter and weak promoter, strong enhancer and weak/poised enhancer, insulator, transcriptional region and heterochromatin/low signal, respectively.
