Figure 1 | Scientific Reports

Figure 1

From: CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

Figure 1

Defective hematopoiesis in BM of CXCR4−/− chimeras.

(a) BM sections from CXCR4+/+ and CXCR4−/− chimeras were stained with hematoxylin/eosin/safran. Chimeric mice were analyzed 3, 8 and 64 weeks after engraftment of eight-week-old, lethally irradiated mice with 5 × 106 CXCR4+/+ or CXCR4−/− FL cells. (b) Total donor-derived LSK-SLAM cell numbers in BM. Mean ± SEM from 3 independent experiments (5–7 mice per group). (c) Restored hematopoietic reconstitution potential by retroviral expression of CXCR4 in CXCR4−/− HSCs. Mean ± SEM of the percentages of donor-derived BM cells 14 and 24 weeks post engraftment. Data represent a pool from 8 mice over two independent experiments.

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