Figure 1
Behavioral effects induced by the intraplantar (i.pl.) administration of capsaicin (0.03–1.00 μg) in wild-type mice.
(A) Time course (0–15 min) of acute pain behaviors (duration of licking or biting) after the administration of capsaicin or its vehicle (DMSO 1%, dose 0). (B) Latency to paw withdrawal in response to the application of a punctate mechanical stimulus at 0.5 g force 15 min after the i.pl. administration of capsaicin or its vehicle. Animals were always stimulated in the injected paw. (A and B) Each point or bar and vertical line represents the mean ± SEM of values obtained in 8–10 animals. Statistically significant differences between the values obtained in capsaicin- and vehicle-treated animals: **p < 0.01 (two-way repeated measures ANOVA for A, and one-way ANOVA for B; the Bonferroni post hoc test was used for all comparisons).
