Figure 5
The synergic effects of concomitant l-THP and BD1047 (BD) treatment on chronic constriction injury (CCI)-induced mechanical allodynia (MA) and walking track analysis.
(A) The low dose of l-THP or BD1047 treatment alone did not affect MA on day 7 after CCI. However, when a combination of l-THP and BD1047 was given, MA was reduced compared with the effects shown in either the l-THP or BD1047 alone treatment groups. (B) The low dose of l-THP or BD1047 treatment alone had no effect on the percentage of paw print area assessed in the CatWalk analysis. However, the combination of two treatments enhanced the decreased paw print area of the ipsilateral paw on day 7 after CCI. (D) The concomitant treatment with a low dose of l-THP and a low dose of BD1047 also showed synergic antinociceptive effect on the ipsilateral paw single stance. (n = 5–7, per group) *BD + l-THP, *P < 0.05, **P < 0.01, ***P < 0.001; #l-THP, #P < 0.05 as compared with those of the vehicle group.
