Figure 6 | Scientific Reports

Figure 6

From: Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor

Figure 6

Inhibitory effect of l-THP on chronic constriction injury (CCI)-induced pNR1 expression.

As compared with sham group, CCI remarkably increased the phosphorylation of NMDA NR1 subunit (pNR1) expression. Treatment of BD1047 (BD), l-THP and gabapentin (GBP) significantly reduced the pNR1 expression in ipsilateral dorsal horn as compared with that of vehicle group. (n = 5 per group) *P < 0.05 and ***P < 0.001 as compared with those of the vehicle group.

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