Table 4 The antibiotic resistance of C. difficile in Mainland China in the past 6 years.

From: The incidence and drug resistance of Clostridium difficile infection in Mainland China: a systematic review and meta-analysis

Antimicrobial agents

Drug resistance (95%CI) (%)

Chi-squared

P

I-squared

Model

n/N

References

Metronidazole

0

—

—

—

—

0/960

23, 24, 25, 26, 27, 28, 29, 40, 54, 94

Vancomycin

0

—

—

—

—

0/960

23, 24, 25, 26, 27, 28, 29, 40, 54, 94

Tigecycline

0

—

—

—

—

0/41

27, 94

Piperacillin/Tazobactam

0

—

—

—

—

0/288

24, 40, 54

Erythromycin

80.2(73.5–86.9)

8.26

0.041

63.70%

REM

340/433

25, 26, 40, 54, 94

Clindamycin

81.7(76.1–87.3)

13.08

0.023

61.80%

REM

476/581

24, 25, 26, 27, 29, 40, 54, 94

Tetracycline

46.8(36.7–56.9)

15.9

0.001

81.10%

REM

231/498

26, 29, 40, 54

Moxifloxacin

39.0(27.9–50.1)

38.79

0

84.50%

REM

247/549

24, 25, 26, 29, 40, 54, 94

Ciprofloxacin

98.3(96.9–99.7)

0

—

—

FEM

688/694

28, 29, 40, 54

Fusidic acid

16.8(5.4–28.2)

21.06

0

90.50%

REM

72/404

26, 40, 54

Rifampicin

18.3(7.2–29.4)

59.61

0

93.30%

REM

89/527

25, 26, 29, 40, 54, 94

Rifaximin

22.1(17.1–27.0)

2.48

0.115

59.70%

FEM

60/600

28, 40, 54

Meropenem

8.8(−8–25.6)

6.25

0.012

84.00%

REM

11/388

24, 27, 28

Levofloxacin

60.2(44.4–75.9)

97.42

0

94.9%

REM

436/779

26, 27, 28, 40, 54, 94

  1. n: number of drug resistant strains; N: total number of C. difficile strains from the included studies.
  2. “—” The data were not applied to the statistical calculation.
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