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Figure 1

From: Impaired Endothelial Nitric Oxide Synthase Homodimer Formation Triggers Development of Transplant Vasculopathy - Insights from a Murine Aortic Transplantation Model

Figure 1

Neointima formation.

Aortic grafts were taken from tetrahydrobiopterin (BH4) - treated or non-treated donors, subjected or not subjected to 24 h CIT, and reperfused for 4 weeks. H&E and Elastica van Gieson staining: (a+b) allogeneic non-treated with CIT (group I, n = 10), (c+d) allogeneic BH4 – treated with CIT (group II, n = 9), (e+f) allogeneic non-treated without CIT (group III, n = 9), (g+h) syngeneic control group with CIT (group IV, n = 5). Closed bars in (a–d) indicate the neointima. Black-staining in (b,d,f,h) indicates elastic fibers of the vessel wall. Bar graphs showing (i) intima thickness (μm) and (j) the intima:media ratio. Results are expressed as mean ± SEM. ns = not significant.

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