Table 1 Characteristics of the studies included in the meta-analysis. NO. = number of patients, NA = not available.
Author | Year | Country | No. | Stage | IHC evaluation method | Antibody | Cut-off | PD-L1 positive (%) | Outcome | HR estimation | Quality Assessment (score) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
company | source | type | clone | |||||||||||
Wu | 2006 | China | 102 | I-IV | Percentage of positive cells and staining intensity | Shuzhou university, China | NA | MAB | 2H11 | NA | 43/102 (42.2) | OS | HR and 95% CI 2.80 (1.05–7.48) | 7 |
Geng | 2015 | China | 100 | I-IV | Percentage of positive cells and staining intensity | Novus, USA | NA | MAB | 2H11 | H-score≥ 3 | 65/100 (65) | OS | HR and 95% CI 1.65 (1.16–2.73) | 7 |
Hou | 2014 | China | 111 | I-IV | Percentage of positive cells | Abcam, UK | Rabbit | PAB | NA | ≥10% | 70/11 (63.1) | OS | Survival curves 1.30(0.58–2.94) | 7 |
Kim | 2016 | Japan | 243 | I-III | Percentage of positive cells and staining intensity | Abcam, UK | Rabbit | PAB | NA | ≥10% amd Moderate or strong staining | 106/243 (43.6) | OS | Survival curves 0.63(0.36–1.09) | 7 |
Qing | 2015 | China | 107 | I-III | Percentage of positive cells | GeneTex, USA | NA | PAB | NA | ≥10% | 54/107 (50.5) | OS | Survival curves 2.28(1.25–4.16) | 6 |
Tamura | 2015 | Japan | 431 | I-IV | Percentage of positive cells | Abcam, Japan | Rabbit | PAB | NA | ≥51% | 128/431(29.6) | OS | HR and 95% CI 2.34 (1.63–3.37) | 7 |
Wang | 2015 | China | 105 | NA | Percentage of positive cells | Gene Tex, USA | NA | PAB | NA | ≥10% | 52/105 (49.5) | OS | HR and 95% CI 1.93 (1.12–3.32) | 6 |
Zhang | 2015 | China | 132 | II-III | Staining intensity | Abcam, UK | Rabbit | PAB | ab58810 | Moderate or intense staining | 67/132 (50.8) | OS | Survival curves 2.71(1.40–5.23) | 7 |
Christine | 2016 | German | 465 | I-IV | Percentage of positive cells and staining intensity | CellSignaling, USA | Rabbit | MAB | E1L3N | IRS>2 | 140/465(30.1) | OS | HR and 95% CI 0.75 (0.58–0.97) | 8 |
Eto | 2016 | Japan | 105 | II-III | Percentage of positive cells | Abcam, UK | Rabbit | MAB | ab174838 | ≥51% | 26/105 (25) | OS | Survival curves 3.29(0.93–11.63) | 7 |
