Figure 7 | Scientific Reports

Figure 7

From: Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

Figure 7

LPS increases the rate of aerobic glycolysis in airway epithelial cells.

(A) Glycolysis rate of LPS-treated Calu-3 cells (24 hours pre-treatment), calculated by subtracting the normalized ECAR values after 2-Deoxy-D-Glucose (2-DG) injection from the ECAR values after glucose injection, in order to exclude the non-glycolytic acidification from the calculation. (B) Glycolytic capacity of LPS-treated Calu-3 cells (24 hours pre-treatment), calculated by subtracting the non-glycolytic acidification rate (ECAR after 2-DG injection) from the maximum ECAR after 1 μM Oligomycin injection. *P < 0.05, **P < 0.01, n = 11. Data represent the means ± S.E.M.

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