Figure 1

Increased excitatory synaptic activity on LVPNs within the motor cortex in TDP-43^Q331K mutant animals.

(a,b) Show representative traces of EPSCs (inward currents) at a holding voltage of −70 mV in WT and TDP-43^Q331K LVPNs, respectively. (c,d) Show representative traces of IPSCs (outward currents) at a holding voltage of 0 mV in WT and TDP-43^Q331K LVPNs, respectively. (e) Shows a scatterplot with mean ± s.e.m. of increased EPSC frequency (Hz) in TDP-43^Q331K LVPNs (n = 10) compared to WT age- and litter-matched controls (n = 11), **P < 0.01, Mann Whitney test. (f) Shows a scatterplot with mean ± s.e.m. of unchanged IPSC frequency (Hz) in TDP-43^Q331K LVPNs (n = 10) compared to WT age- and litter-matched controls (n = 11), Students unpaired two-tailed t test. (g) Shows a scatterplot with mean ± s.e.m. of increased synaptic drive ratio (EPSC frequency/IPSC frequency) in TDP-43^Q331K LVPNs (n = 10) compared to WT age- and litter-matched controls (n = 11), *P < 0.05, students unpaired two-tailed t test.