Table 1 EPSC and IPSC parameters of LVPNs within the motor cortex.

From: Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

Parameter

WT (n = 11)

TDP-43Q311K (n = 10)

P value

EPSC frequency (Hz)

1.48 ± 0.23

3.67 ± 0.50

**0.001a

EPSC amplitude (pA)

−9.89 ± 1.86

−7.55 ± 1.96

0.40

EPSC rise time (ms)

3.65 ± 0.37

3.67 ± 0.49

0.97

EPSC half-width (ms)

2.93 ± 0.38

2.13 ± 0.35

0.14

IPSC frequency (Hz)

3.19 ± 0.48

4.38 ± 0.64

0.15

IPSC amplitude (pA)

25.02 ± 5.59

11.30 ± 6.51

0.12

IPSC rise time (ms)

7.31 ± 1.94

9.32 ± 1.30

0.40

IPSC half-width (ms)

7.80 ± 1.71

10.88 ± 3.12

0.39

Synaptic drive ratio (E/I)

0.52 ± 0.09

0.92 ± 0.12

*0.01

  1. All data presented as mean ± s.e.m., number of cells (n) in parenthesis. *P < 0.05, **P < 0.01, Student’s two-tailed unpaired t-test, excepta, Mann Whitney test.
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