Table 2 General morphological parameters and dendritic spine density (spines per 100 μm of dendrite) of LVPNs within the motor cortex.
Parameter | WT (n = 12) | TDP-43Q311K (n = 11) | P value |
|---|---|---|---|
Soma volume (μm3) | 2,546 ± 307 | 2,241 ± 300 | 0.49 |
Total dendrite length (μm) | 4,566 ± 651 | 3,765 ± 581 | 0.37 |
Mean apical tree length (μm) | 2,082 ± 381 | 2,038 ± 436 | 0.94 |
Max apical terminal length (μm) | 517.9 ± 39.3 | 613.5 ± 51.5 | 0.15 |
Total basal tree length (μm) | 2,410 ± 338 | 1,727 ± 173 | 0.19a |
Mean basal tree length (μm) | 288.1 ± 47.4 | 228.4 ± 31.1 | 0.31 |
Total spine density | 44.1 ± 5.8 | 67.3 ± 7.4 | *0.02 |
Total apical spine density | 45.8 ± 5.0 | 67.7 ± 7.8 | *0.03 |
Proximal apical spine density | 28.4 ± 3.9 | 44.5 ± 6.4 | *0.04 |
Distal apical spine density | 49.2 ± 5.7 | 77.7 ± 7.5 | **0.006 |
Total basal spine density | 42.2 ± 7.3 | 65.3 ± 7.1 | *0.03 |
Proximal basal spine density | 31.8 ± 3.8 | 55.5 ± 6.6 | **0.004 |
Distal basal spine density | 47.4 ± 8.4 | 72.4 ± 7.0 | *0.03 |
