Table 3 Dendritic morphology of tufted and slender LVPNs within the motor cortex in TDP-43Q331K compared to WT.

From: Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

Parameter

Tufted (n = 7)

Slender (n)

ANOVA P

Max apical terminal length (μm)

WT: 573 ± 60 TDP-43: 3,751 ± 750

WT: 441 ± 9 (5) TDP-43: 451 ± 73 (4)

Type: P = 0.002 **Geno: P = 0.18

Total dendrite length (μm)

WT: 5,559 ± 746 TDP-43: 4,675 ± 700

WT: 3,177 ± 895 (5) TDP-43: 2,173 ± 221 (4)

Type: P = 0.005 **Geno: P = 0.23

Mean apical tree length (μm)

WT: 2,862 ± 444 TDP-43: 2,677 ± 548

WT: 1,045 ± 168 (5) TDP-43: 918 ± 192 (4)

Type: P = 0.001 **Geno: P = 0.74

Mean basal tree length (μm)

WT: 309 ± 64 TDP-43: 262 ± 44

WT: 258 ± 77 (5) TDP-43: 178 ± 10 (4)

Type: P = 0.28 Geno: P = 0.30

Apical nodes & endings

WT: 65 ± 7.4 TDP-43: 55 ± 11

WT: 25 ± 4.7 (5) TDP-43: 23 ± 4.9 (4)

Type: P < 0.001 ***Geno: P = 0.54

Basal nodes & endings

WT: 47 ± 6.6 TDP-43: 46 ± 11

WT: 40 ± 11 (5) TDP-43: 31 ± 3.4 (4)

Type: P = 0.20 Geno: P = 0.58

Total spine density

WT: 46.4 ± 8.2 TDP-43: 72.6 ± 11.9

WT: 40.8 ± 8.5 (5) TDP-43: 60 ± 7.7 (4)

Type: P = 0.39 Geno: P = 0.04*

Apical spine density

WT: 46.1 ± 5.7 TDP-43: 70.9 ± 11.5

WT: 45.4 ± 9.9 (5) TDP-43: 62 ± 8.5 (4)

Type: P = 0.62 Geno: P = 0.04*

Apical distal spine density

WT: 50.3 ± 6.6 TDP-43: 83.6 ± 10.6

WT: 47.5 ± 10.9 (5) TDP-43: 67.6 ± 8.3 (4)

Type: P = 0.34 Geno: P = 0.01*

Basal spine density

WT: 45.8 ± 11.2 TDP-43: 69 ± 10.6

WT: 36.6 ± 7.8 (5) TDP-43: 58.6 ± 7.3 (4)

Type: P = 0.37 Geno: P = 0.04*

  1. All data presented as mean ± s.e.m., number of cells (n) in parenthesis. All analysis are two-way ANOVAs for neuronal subtype and genotype where *P < 0.05. Bonferroni post-tests showed were all P > 0.05.
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