Table 4 No significant sex differences of general morphologic parameters and dendritic spine density (spines per 100 μm of dendrite) of LVPNs within the motor cortex.

From: Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

Parameter

Female (n)

Male (n)

ANOVA P

Total dendrite length (μm)

WT: 4,201 ± 1,028 (6) TDP-43: 3,751 ± 750 (4)

WT: 4,932 ± 869 (6) TDP-43: 3,986 ± 800 (7)

Sex: P = 0.60 Geno: P = 0.46

Mean apical tree length (μm)

WT: 2,047 ± 670 (6) TDP-43: 1,950 ± 435 (4)

WT: 2,116 ± 869 (6) TDP-43: 2,089 ± 652 (7)

Sex: P = 0.86 Geno: P = 0.92

Mean basal tree length (μm)

WT: 280 ± 64 (6) TDP-43: 223 ± 40 (4)

WT: 330 ± 88 (6) TDP-43: 232 ± 46 (7)

Sex: P = 0.66 Geno: P = 0.26

Total spine density

WT: 39.5 ± 7.4 (6) TDP-43: 56.2 ± 7.2 (4)

WT: 48.6 ± 9.1 (6) TDP-43: 73.7 ± 10.5 (7)

Sex: P = 0.18 Geno: *P = 0.04

Apical spine density

WT: 45.4 ± 8.5 (6) TDP-43: 60.2 ± 8.4 (4)

WT: 46.3 ± 8.4 (6) TDP-43: 72.0 ± 11.4 (7)

Sex: P = 0.51 Geno: *P = 0.04

Basal spine density

WT: 38.2 ± 6.6 (6) TDP-43: 56.9 ± 8.0 (4)

WT: 48.2 ± 13.6 (6) TDP-43: 74.1 ± 9.0 (7)

Sex: P = 0.23 Geno: *P = 0.03

  1. All data presented as mean ± s.e.m., number of cells (n) in parenthesis. All analysis are two-way ANOVAs for sex and genotype where *P < 0.05. Bonferroni post-tests showed were all P > 0.05.
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