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Figure 1

From: Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells

Figure 1

Dendritic cells regulate NK cell homeostasis and maturation status.

(a) Kinetic analysis of NK cell numbers in spleen and bone marrow. (b) Kinetic of NK cell apoptosis (Annexin V+ Vivid+) (left panel) and proliferation (Ki67+) in the spleen. (c) Maturation of splenic NK cells at the start (Day 0) and at 8 days after the onset of DT administration (Day 8). (d) A kinetic analysis of NK cell maturation in the spleen analyzed by a combination of markers for CD27 and CD11b. (e) NK cell maturation status on proliferating (Ki67+) cells in the presence or absence of DCs for 6 days.*p < 0.05, ***p < 0.001 (unpaired two-tailed Student’s t-test). Data shown are combined from 2 independent experiments (a,b,d), representative of 2 experiments (c,e). Error bars, SEM ([n = 5–10] mice per group [a,b,d], 5 mice per group [e]).

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