Figure 2 | Scientific Reports

Figure 2

From: Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells

Figure 2

Altered receptor expression on NK cells upon DC depletion.

(a) Expression of activating receptors on NK cells from the spleen. CD11c.DOG mice (white bars) were injected with DT daily for 1, 2, and 4 days and compared to data from littermate controls (black bar) at day 0. (b) Inhibitory receptor repertoire on NK cells upon 10 days of DT injection. Five inhibitory receptors, including Ly49C, Ly49I, Ly49A, Ly49G2, and NKG2A were analyzed. (c) Percentages of Ly49-negative subsets (negative for 5 inhibitory receptors tested) upon daily DT injection for 2, 4, 6, 8, or 10 days. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 (unpaired two-tailed Student’s t-test). Data shown are combined from 3 independent experiments (a,b,c). Error bars, SEM (n = 4 to 10 mice per group [A], n = 8 to 10 mice per group [b,c]).

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