Table 1 Functional biological process-enrichment analysis of differentially expressed genes (1.3 folds).
Rank | Biological processa | Enrichmentb (Fold) | P valuec | Genes present |
|---|---|---|---|---|
Processes enriched for down-regulated genes(149 genes) | ||||
1 | Immune response | 3.8 | 1.4E-4 | Cd74, Ang4, Ccl4, Cxcl10, Crtam, Lilrb4, Gp49a, H2-Ab1, Il4ra, Il7r, Ltb, Ncf1, Ccl27a, Tnfsf10 |
2 | Regulation of cell killing | 18 | 1.3E-3 | Crtam, Il7r, Lag3, P2rx7 |
3 | Positive regulation of immune system process | 4.7 | 3.7E-3 | Cd38, Cd74, Il4ra, Crtam, Il7r, Lag3, P2rx7 |
5 | Lipid transport | 5.8 | 1.1E-2 | Atp8a2, Cpt1b, Pltp, Kcnn4, P2rx7 |
6 | Programmed cell death | 2.6 | 2.1E-2 | Ahr, Kit, Ltb, Ncf1, Pmaip1, Phlda1, Mrpl41, Ppp1r15a, Tnfsf10 |
7 | Positive regulation of macromolecule metabolic process | 2.2 | 3.9E-2 | Bcl11b, Cited4, Fos, Jun, Ahr, Hes1, Kit, Ltb, Nr4a2, P2rx7 |
Processes enriched for up-regulated genes(143 genes) | ||||
1 | DNA packaging | 18 | 8.6E-13 | Asf1b, H2afz, Hells, Hist1h1a, Hist1h1b, Hist1h2ab, Hist1h2bb, Hist1h2bc, Hist1h2bh, Hist1h3g, Hist1h4h, Hist1h4b, Hist1h4c, Hist2h4, Hist1h4f, Hist4h4, Hist2h2ab, Nusap1, Hist1h2bj |
2 | Cell division | 8.6 | 5.2E-12 | Anln, Aspm, Aurkb, Bub1, Bub1b, Cdca7, Cdca8, Cenpe, Ccna2, Ccnb2, Ccne2, Hells, Kif11, Lig1, Nusap1, Plk1, Cks1b, Sgol2, Ube2c |
3 | Microtubule-based movement | 10 | 1.4E-5 | Cenpe, Kif11, Kif15, Kif18b, Kif20a, Kif23, Kif4, Tubb1 |
4 | DNA metabolic process | 3.6 | 4.4E-4 | Prim1, Rad51, Clspn, Ccne2, Exo1, Hells, Lig1, Mcm7, Neil3, Pole, Rrm2, Uhrf1 |
5 | Cell proliferation | 4.1 | 3.2E-3 | E2f8, Mki67, Aspm, Hells, Itgad, Mcm7, Vpreb1, Uhrf1 |
