Figure 7 | Scientific Reports

Figure 7

From: Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells

Figure 7

A schematic representation of signaling responses to AKT inhibition and PD combination.

AKT inhibition by pharmacological and siRNA mediation activates a feedback increase in EGFR and HER-2. PD could decrease EGFR and HER-2, and inhibit the phosphorylation of AKT and 4E-BP1. Upregulated EGFR and HER-2 upon AKT inhibition were reversed by PD, accompanied by the blockade of AKT signaling and downstream 4E-BP1, causing the enhanced response to AKT inhibition. PD, platycodin D; siRNA, Small interfering RNA.

Back to article page