Figure 1
From: Rapid control of pandemic H1N1 influenza by targeting NKT-cells
Intranasal α-GalCer administration reduces flu symptoms and restores body weight gain in IAV-infected pigs.
(a,b) Health scores reported for individual pigs and mean ± standard error of the mean (SEM) for each treatment group on days 1, 2, 3 and 5 post infection (p.i.). (a) Fecal score: ranked from 0 to 3; 0: normal; 1: semi-solid; 2: liquid; 3: watery, presence of mucous or blood. (b) Nasal secretion: observed to be clear and serosa for all animals; ranked from 0 to 3, as 0: absent; 1: small volume discharge, from one nostril; 2: small volume, both nostrils; 3: large volume, both nostrils. (c) Percentage body weight gain compared to day −1 p.i. for SI virus-challenged pigs mock-treated with MEM (Mock/CA04) or treated with 100 μg/kg α-GalCer administered i.m. (IM αGC/CA04) or i.n. (IN αGC/CA04). Control pigs were mock challenged and mock-treated with MEM (Mock/Mock). Differences in weight gain were analyzed using the Kruskal-Wallis test. *P < 0.05. Data are represented as mean ± SEM.
