Figure 6 | Scientific Reports

Figure 6

From: Cellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17

Figure 6

Secretion of p17 protein is blocked by specific inhibitors of γ-secretase inhibitors.

Jurkat-Gag were cultured for 16 h in ELISA plates in the presence or absence of the specific γ-secretase inhibitors Avagacestat and LY411575. Box plots represent statistical analyses of six independent experiments. (A) Avagacestat and (B) LY411575 inhibit p17 release in a dose-dependent manner. Significance was assessed using one-way ANOVA and the Bonferroni’s post-test (***P < 0.001).

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