Table 1 Summary of included studies evaluating smoking and its association with ERM.

From: The Association between Smoking and Epiretinal Membrane

Source (Publication Year,Country)

Design

Study Period

Population (Sample Size)

Age Range* (Yrs)

Smoking Status

ERM Classification

ERM definition and grating

ERM Prevalence (%, 95% CI)

Adjusted variables

Ye et al.41 (2015 China)

Cross-sectional

2012–2013

Jiangning Eye Study, population-based (N = 2,005)

≥50

Never; Past; Current

Any ERM CMR PMF

Fundus photography, OCT images

Any ERM 7.3 (6.2–8.5) CMR 4.3 (3.4–5.2) PMF 3.0 (2.3–3.8)

None

Aung et al.18 (2013 Australia)

Cohort

2003–2007

Melbourne Collaborative Cohort Study, volunteers (N = 21,241)

65.2 ± 5.8

Never; Former; Current

Any ERM CMR PMF

Retinal imges

Any ERM 8.9 (8.48–9.25) CMR 4.9 (4.64–5.22) PMF 3.9 (3.67–4.19)

None

Ng et al.17 (2011 USA)

Cross-sectional

2000–2002

Multi-Ethnic Study of Atherosclerosis, population-based (N = 5960)

62

Current; Never;

Any ERM CMR PMF

Digital non-stereoscopic fundus photographs

Any ERM 28.9 CMR 25.1 PMF 3.8

Age, gender, ethnicity, study center

Duan et al.9 (2009 China)

Cross-sectional

2006–2007

Handan Eye Study, population-based (N = 6,565)

51.7 ± 11.6

Never; Past; Current

Any ERM CMR PMF Unclassified (by OCT only)

Retinal photograph and/or OCT

Any ERM 3.4 (2.9–3.8) CMR 2.2 PMF 0.7 Unclassified 0.5 0.3–0.6

Age, sex

Kawasaki et al.10 (2009 Japan)

Cohort

2000–2002

Funagata study, population-based (N = 1723)

64.9

Never; Past; Current

Any ERM CMR PMF

Non-mydriatic fundus photographs

Any ERM 5.7 (4.5–7.0) CMR 4.1 (3.0–5.2) PMF 1.6 (0.9–2.3)

None

Kawasaki et al.16 (2008 Singapore)

Cross-sectional

2004–2006

Singapore Malay, population-based (N = 3,265)

40–80

Never; Past; Current

Any ERM CMR PMF

Fundus photograghs

Any ERM 7.9 (7.1–8.7) CMR 3.8 (3.3–4.4) PMF 4.1 (3.4–4.7)

Age, gender

McCarty et al.40 (2005 Australia)

Cross-sectional

1992–1997

Visual Impairment Project, population-based (N = 4,313)

60.1 ± 12.8

Smoking history (Not clearly defined)

Any ERM CMR PMF

Fundus photograghs

Any ERM 6.0 (5.2–6.7) CMR 4.8 (4.0–5.6) PMF 1.7 (1.2–2.3)

Age, sex

Miyazaki et al.12 (2003 Japan)

Cross-sectional

1998

Hisayama study, population-based (N = 1,765)

≥40

Current habitual user; Nonuser

Any ERM CMR PMF

Indirect ophthalmoscopy, slit lamp, and color fundus photographs

Any ERM 4.0 CMR NA PMF NA

Age

  1. ERM, epiretinal Membrane, CMR, cellophane macular reflex, PMF, preretinal macular fibrosis. *As limited information was provided, we failed to display age of participants in a uniform way, we extracted age range or mean with or without Standard deviation.