Figure 1
Intravenous injection of S. aureus in mice results in a rapid infection of bones and joints.
(A) 2D Ventral pictures of a representative CD1 mouse intravenously infected with S. aureus Xen36 bioluminescent strain from day 1 (d1) to day 7 (d7) p.i. (B) Correlation analysis between CFU counts and BLI intensity at day 7 p.i. Spearman’s r value and significance are reported. (C) Quantification of the bioluminescent (BLI) signals belonging to the knee joint areas of infected animals from day 0 (naïve mice, before infection) to day 7. Median values of 5 animals at each time point are reported together with interquartile ranges. (D) 3D analysis of BLI signals from animals infected with Xen36 strain. A ventral picture of 1 animal out of 5 at day 2 p.i. is shown. In the panel on the right, an enlargement of the left hind paw is depicted. (E) Confocal microscopy image of a whole knee from one mouse infected with S. aureus Newman strain 7 days after injection. One out of 5 mice is shown.
