Figure 5
Loss of function of CbpL attenuates pneumococci in the acute pneumonia infection model.
(A) Kaplan-Meier survival plot of CD-1 mice infected with D39 wild-type and CbpL-deficient pneumococci. Mice (n = 12) were intranasally infected with 2.0 × 107 CFU of S. pneumoniae D39 wild-type or its isogenic ∆cbpL-mutant. (B) and (C) Bioluminescent optical imaging of pneumococcal dissemination after intranasal infection of CD-1 mice (n = 12). Transmigration of bioluminescent D39lux and D39lux∆cbpL into the lung or blood was analyzed at indicated time points by measuring of the luminescence intensity using the IVIS® Spectrum System. The bioluminescent flux of grouped mice is represented in the box whiskers graph (B).
