Figure 5
From: Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis
(A) The number of Nav1.6-ir positive cells in the ipsilateral hippocampus was closely correlated with the onset of SE in rats with KA intrahippocampal injection (R2 = 0.754, P < 0.01). (B) Regression analysis demonstrating the strong relationship between the number of Nav1.6-ir positive cells in the ipsilateral hippocampus and the severity of SE estimated by the number of stage 5 seizures for rats experiencing SE at 7 days, 21 days and 63 days after SE (at 7 days after SE, R2 = 0.975 P < 0.01; at 21 days after SE, R2 = 0.986, p < 0.01; at 63 days after SE, R2 = 0.941, P < 0.01). (C) The number of Nav1.6-ir positive cells in the ipsilateral hippocampus was profoundly correlated with the severity of astrogliosis in post-SE rats (R2 = 0.899).
