Figure 6
From: Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis
Colocalization of Nav1.6 (red) with GFAP (green) in the hippocampus in KA induced TLE rats.
(A,B) Rare Nav1.6 is colocalized with the astrocytic marker GFAP in the CA1 and CA3 subregions in the hippocampus in the controls. (C,D) Nav1.6 is highly colocalized with the astrocytic marker GFAP in the CA1 and CA3 subregions in the ipsilateral hippocampus at 21 days after-SE in KA induced TLE rats. (E,F) Note Nav1.6-ir is extensively distributed in the soma and process of GFAP-ir positive cells in the ipsilateral hippocampus at 21 days after-SE in KA induced TLE rats at high magnification. The colocalization ratios of Nav1.6 with GFAP in the hippocampal CA1 and CA3 subregions in KA induced TLE rats and the controls are shown in (G,H). Data are plotted as mean ± SEM of five animals in each group. SO: stratum oriens; SR: stratum radiatum; SL: stratum lucidum; SP: stratum pyramidale. *P < 0.05, **P < 0.01, significantly different from control animals.
