Figure 8
Peak current (A,B) or late current (C,D) ACh concentration-response curves in the absence (●) or presence (■) of PhTX-12 at 10 μM (peak current) or 0.3 μM (late current) for α3β4 and α1β1γδ.
Curves were fitted with Eq. 2 and EC50 values are given in Table 3. The grey symbols (
) show the % control response for each ACh concentration in the presence of PhTX-12. E-F: α3β4 currents in response to 100 μM (E) or 1 mM ACh in the absence (black) and presence (blue) of 10 μM PhTX-12. VH = −80 mV in all cases.
