Table 3 ACh EC50 values in the absence and presence of PhTX-343 or PhTX-12.

From: Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

 

[PhTX-343]

ACh EC50 (95% CI), μM

Control

+PhTX-343

α4β2

1 μM

13

(8.9–20)

22

(5.6–89)

α4β4

1 μM

17

(8.4–36)

14

(7.8–25)

α3β4

1 μM

78

(67–91)

89

(38–207)

α3β2

1 μM

16

(12–20)

13

(9.4–18)

α7

30 μM

245

(198–304)

388*

(265–568)

α1β1γδ

10 μM

25

(18–35)

54*

(37–80)

 

[PhTX-12]

Control

+PhTX-12

α3β4

10 μM

141

(113–175)

545****

(331–897)

α1β1γδ

10 μM

17

(15–20)

91****

(48–170)

  1. ACh EC50 values estimated from peak current concentration-response curves in the absence and presence of PhTX-343 or PhTX-12 shown in Figs 6 and 7. *p < 0.05 and ****p < 0.0001 when compared to the EC50 in the absence of toxin by an extra sum of squares F-test.
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