Table 2 In vivo validation of thyroid toxicity signatures at PND360.

	Gene name	ETU mg/kg/day			CPF mg/kg/day			ETU + CPF mg/kg/day
	Gene name	0.1	1	10	0.1	1	10	0.1	10
1	Zfp36l2	−1.51	−1.99*	−2.17**	−1.14	−1.83*	−1.49	−1.78*	−3.14**
2	Hmga1	1.3	−1.07	−1.42*	−1.05	−1.14	−1.27	−1.34	−1.15
3	Egr1	1.49	−1.41	−2.6**	−1.29	−1.88*	−1.59	−1.59	−2.6*
4	Ergic1	−1.2	−1.3	−1.47*	−1.12	−1.16	−1.19	−1.23	−1.59
5	Zfp524	−1.67	1.01	−1.4*	1.31	1.01	1.11	1.04	−1.11
6	Ifit3	−1.61	−1.17	−2.68	1.04	1.05	−1.12	−2.14	−1.01
7	Fz5	−2.55*	−2.8**	−4.6**	−1.2	−3.04**	−3.24**	−2.01*	−2.27
8	Gnao1	−1.77	−2.03	−2.04	−1.6	−1.57	−2.16*	−1.93	−1.32
9	Runx2	1.1	1	−1.51	1.4	−1.21	−1.13	−1.1	−1.26

Transcript level of genes in common- (1–3), ETU- (4–6) and CPF- (7–9) signatures was validated by RT-qPCR. Data are reported as FC vs controls. In bold the ones reaching statistical significance.

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