Figure 4

The correlation between Vpx-mediated SAMHD1 degradation and predictors of HIV disease in chronically HIV-1 infected patients.

The relationship of SAMHD1 degradation by SIV-Vpx in activated CD4⁺ T cells with CD4 counts (a), the number of activated CD4⁺ T cells (c), or blood IFN-α level (e). Correlation between SAMHD1 degradation by SIV-Vpx in CD14⁺ monocytes and CD4⁺ T-cell counts (b), the number of activated CD4⁺ T cells (d), or blood IFN-α level (f). Subjects with CD4 counts and the number of activated CD4⁺ T cells were from cART-naive populations (n = 22); subjects with blood IFN-α level were from HIV-1 infected individuals (n = 15). r, Spearman’s correlation coefficient; p < 0.05 was considered to indicate a statistically significant result.