Table 4 Univariate and multivariate analysis for overall, cancer-specific and recurrence-free survival in the patients with pT3 UTUC.
From: Adjuvant radiotherapy for locally advanced upper tract urothelial carcinoma
Overall survival | Cancer-specific survival | Recurrence-free survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |||||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Gender | 1.21 (0.78–1.89) | 0.391 | 1.01 (0.57–1.77) | 0.981 | 1.39 (0.85–2.27) | 0.188 | 1.35 (0.72–2.55) | 0.353 | 1.25 (0.80–1.96) | 0.323 | 1.27 (0.73–2.22) | 0.403 |
Advanced age* | 1.54 (1.22–1.94) | 0.000 | 1.47 (1.14–1.88) | 0.003 | 1.56 (1.21–2.01) | 0.001 | 1.43 (1.09–1.88) | 0.011 | 1.31 (1.05–1.65) | 0.019 | 1.25 (0.98–1.60) | 0.075 |
Current smoking | 1.00 (0.73–1.38) | 0.979 | 1.16 (0.78–1.74) | 0.466 | 1.01 (0.71–1.44) | 0.948 | 1.28 (0.81–2.03) | 0.292 | 1.04 (0.75–1.45) | 0.811 | 1.20 (0.80–1.80) | 0.389 |
ASA score | 0.972 | 0.798 | 0.730 | 0.255 | 0.225 | 0.120 | ||||||
Recurrent bladder tumor | 1.40 (0.82–2.39) | 0.220 | 1.23 (0.69–2.21) | 0.477 | 1.19 (0.68–2.09) | 0.542 | 1.01 (0.55–1.85) | 0.986 | 1.02 (0.62–1.69) | 0.926 | 1.30 (0.75–2.26) | 0.344 |
Recurrent contralateral UTUC | 1.15 (0.70–1.90) | 0.586 | 1.08 (0.64–1.83) | 0.767 | 1.49 (0.74–3.01) | 0.270 | 1.50 (0.73–3.09) | 0.274 | 1.17 (0.71–1.94) | 0.533 | 1.23 (0.72–2.08) | 0.446 |
CKD† | 1.33 (1.00–1.77) | 0.052 | 1.50 (1.09–2.06) | 0.012 | 1.42 (1.06–1.90) | 0.019 | 1.64 (1.18–2.28) | 0.003 | 1.38 (1.06–1.82) | 0.019 | 1.66 (1.23–2.24) | 0.001 |
Tumor grade | 1.32 (0.65–2.66) | 0.444 | 1.59 (0.75–3.37) | 0.224 | 1.22 (0.61–2.47) | 0.575 | 1.63 (0.77–3.48) | 0.205 | 1.12 (0.63–1.99) | 0.706 | 1.26 (0.68–2.34) | 0.457 |
LVI | 1.64 (1.29–2.08) | 0.000 | 1.69 (1.30–2.19) | 0.000 | 1.68 (1.30–2.17) | 0.000 | 1.79 (1.35–2.37) | 0.000 | 1.55 (1.22–1.99) | 0.000 | 1.63 (1.24–2.14) | 0.000 |
CIS | 1.40 (1.07–1.83) | 0.015 | 1.19 (0.88–1.61) | 0.269 | 1.37 (1.02–1.84) | 0.038 | 1.14 (0.81–1.60) | 0.450 | 1.46 (1.12–1.91) | 0.006 | 1.37 (1.02–1.85) | 0.038 |
Positive surgical margin | 1.57 (1.11–2.24) | 0.012 | 1.64 (1.11–2.44) | 0.014 | 1.65 (1.16–2.36) | 0.005 | 1.76 (1.16–2.67) | 0.008 | 1.48 (1.04–2.10) | 0.027 | 1.73 (1.16–2.57) | 0.007 |
Radiotherapy | 0.99 (0.57–1.72) | 0.979 | 0.59 (0.29–1.23) | 0.158 | 0.94 (0.51–1.73) | 0.844 | 0.60 (0.27–1.34) | 0.213 | 0.92 (0.53–1.62) | 0.777 | 0.71 (0.34–1.50) | 0.371 |
Chemotherapy | 0.68 (0.43–1.07) | 0.099 | 0.42 (0.24–0.74) | 0.003 | 0.57 (0.32–1.01) | 0.056 | 0.33 (0.17–0.66) | 0.002 | 0.69 (0.44–1.09) | 0.113 | 0.43 (0.24–0.76) | 0.004 |
