Figure 6 | Scientific Reports

Figure 6

From: Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface

Figure 6

Model for 10E8 epitope binding at the viral membrane interface.

A silhouette model of the trimer of Env from Lee et al.14 was employed to illustrate the figure. To facilitate the understanding of the model, only two MPER epitopes (green helices) are shown. The antibody is shown in blue, and the critical aromatic cluster depicted as magenta sticks. Orange boxes represent deeper segments of the TMD. Inset: close-up view of the aromatic residue cluster stabilizing the MPER-N-TMD helix at the membrane interface. Residues contributed by Fab and gp41 are depicted in magenta and green, respectively.

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