Figure 4
Effect of FOXA3 on IGF1 promoter activity.
In the absence of FOXA3, there was no gradational transactivation among promoter fragments with different microsatellite lengths. In the presence of FOXA3, the length of microsatellite repeats was significantly associated with the transcriptional activity, the lower the repeat numbers, the higher the transcriptional activity. Relative luciferase activity is shown as mean ± SD. Student’s t test was used for comparison of two haplotypes. Each assay was repeated four times in each of the four independent experiments (n = 16) (***p < 0.001 by student’s t test).
