Figure 1: Feedback loops in the MAPK/ERK pathway.
From: Relaxation oscillations and hierarchy of feedbacks in MAPK signaling
Loops captured in the model are shown with solid lines. The arrow labeled PF1 represents positive feedback. This feedback loop has been implicated in mediating bistable switching. The arrows labeled NF1–NF3 represent negative feedbacks. The NF1 feedback loop encompasses the positive feedback loop. The NF2 and NF3 feedback loops are placed out of the positive feedback loop. Dotted lines indicate feedbacks not included in the model.
