Figure 10: Spatiotemporal dynamics of EGF, RAS activity (RAS-GTP/RAStotal), and ERK activity (ERKpp/ERKtotal) for a cell responding to localized EGF secretion.
From: Relaxation oscillations and hierarchy of feedbacks in MAPK signaling
Shown are sequential snapshots taken from Supplementary Video 1 in the Supporting Information that illustrate the response of a cell to a wave of EGF, which is produced by point sources releasing EGF at random times and locations in a shell surrounding the cell. At each time point, the spatial distribution of EGF at the cell surface is shown in the top row, fraction of activated RAS is shown in the middle row, and the spatial distribution of activated ERK inside the cell is shown in the bottom row (on a cross-section passing through the cell center). Supplementary Table S4 provides information about the parameters that are unique for the spatiotemporal simulations shown here.
