Table 1 Electrophysiological characteristics of layer V fast-spiking interneurons and pyramidal neurons in mPFC.
| Â | Fast-spiking interneurons | Pyramidal neurons | ||
|---|---|---|---|---|
WT (n = 9) | GluN2C KO (n = 7) | WT (n = 12) | GluN2C KO (n = 12) | |
Resting membrane potential (mV) | −58.5 ± 1.2 | −57 ± 0.9 | −63.1 ± 2 | −60.7 ± 1.5 |
Input resistance (MΩ) | 330 ± 22 | 330 ± 38 | 172 ± 15 | 221 ± 22 |
Spike threshold (mV) | −34.8 ± 0.8 | −35.8 ± 0.9 | −36 ± 1.5 | −34.6 ± 1.2 |
Spike amplitude (mV) | 77.4 ± 3.2 | 80.8 ± 3.2 | 105 ± 2.1 | 103 ± 1.8 |
Spike half width (ms) | 0.86 ± 0.04 | 0.81 ± 0.07 | 1.42 ± 0.04 | 1.62 ± 0.06 |
After hyperpolarization (mV) | 38.6 ± 1.4 | 40.2 ± 1.4 | 10.1 ± 0.9 | 11.3 ± 1.1 |
Adaptation ratio | 0.6 ± 0.04 | 0.55 ± 0.04 | 0.32 ± 0.04 | 0.37 ± 0.04 |
