Table 2 Outcomes of included patients who received more than three intravitreal conbercept injections for AMD and DME.

From: Changes in Retinal Nerve Fiber Layer Thickness after Multiple Injections of Novel VEGF Decoy Receptor Conbercept for Various Retinal Diseases

 

Total

AMD

DME

Total number of injections

392

314

78

 

Injection/Non-injection (p)

Injection/Non-injection (p)

Injection/Non-injection (p)

Average IOP (mmHg)

15.5 ± 2.9/15.5 ± 3.0 (0.887)

15.5 ± 2.9/15.4 ± 3.0 (0.641)

15.7 ± 2.8/15.9 ± 2.8 (0.473)

Final follow-up IOP

15.6 ± 2.6/16.0 ± 2.8 (0.476)

15.7 ± 2.7/16.2 ± 2.9 (0.450)

15.4 ± 2.5/15.5 ± 2.6 (0.947)

IOP spike number

31/0

27/0

4/0

IOP elevation during spike (mmHg)

7.1 ± 2.1 (6.0–16.6)

7.0 ± 2.1 (6.0–16.6)

7.7 ± 1.3 (6.3–9.4)

RNFL thickness (μm)

 Month 6

108.1 ± 26.1/108.3 ± 24.2 (0.971)

100.9 ± 12.1/102.1 ± 11.5 (0.656)

135.4 ± 43.8/131.7 ± 41.9 (0.849)

 Final follow-up

106.1 ± 19.4/107.0 ± 17.9 (0.821)

100.6 ± 12.1/102.2 ± 11.9 (0.556)

125.3 ± 27.4/123.5 ± 25.0 (0.872)

  1. AMD: age-related macular degeneration.
  2. DME: diabetic macular edema.
  3. IOP: intraocular pressure.
  4. RNFL: retinal nerve fiber layer.