Table 4 Subgroup analysis of adjusted ORs (95% CIs) of primary outcome according to uric acid quartiles.

From: Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial

Subgroup

Uric acid (μmol/L)

Q1

Q2

Q3

Q4

Ptrend

Pinteraction

Men

<252

252–306

306–365

≥365

  

 Stroke onset age, years

     

0.06

  <60

1.00

1.06 (0.59–1.92)

0.61 (0.33–1.15)

0.44 (0.22–0.86)

0.01

 

  ≥60

1.00

0.80 (0.53–1.21)

0.95 (0.62–1.44)

0.71 (0.46–1.10)

0.22

 

 Baseline SBP, mm Hg

     

0.21

  <160

1.00

0.78 (0.45–1.36)

0.61 (0.35–1.07)

0.54 (0.30–0.97)

0.02

 

  ≥160

1.00

1.04 (0.68–1.59)

1.08 (0.69–1.69)

0.70 (0.44–1.12)

0.20

 

 Cigarette smoking

     

0.42

  No

1.00

0.84 (0.52–1.35)

0.89 (0.54–1.46)

0.68 (0.41–1.13)

0.18

 

  Yes

1.00

1.01 (0.63–1.62)

0.77 (0.47–1.27)

0.56 (0.33–0.94)

0.02

 

 Alcohol consumption

     

0.46

  No

1.00

0.67 (0.44–1.03)

0.83 (0.54–1.27)

0.68 (0.44–1.05)

0.14

 

  Yes

1.00

1.13 (0.69–1.84)

0.84 (0.51–1.39)

0.57 (0.34–0.97)

0.02

 

 Receiving immediate BP reduction

     

0.18

  No

1.00

1.07 (0.70–1.66)

0.79 (0.51–1.24)

0.55 (0.34–0.88)

0.01

 

  Yes

1.00

0.69 (0.44–1.10)

0.83 (0.52–1.33)

0.74 (0.46–1.18)

0.29

 

Women

<203

203–253

253–304.7

≥304.7

  

 Stroke onset age, years

     

0.90

  <60

1.00

1.08 (0.53–2.20)

2.00 (1.01–3.97)

0.96 (0.44–2.09)

0.53

 

  ≥60

1.00

0.94 (0.51–1.72)

1.01 (0.55–1.84)

1.42 (0.81–2.49)

0.19

 

 Baseline SBP, mm Hg

     

0.64

  <160

1.00

3.30 (1.29–8.45)

3.70 (1.46–9.42)

2.09 (0.84–5.24)

0.16

 

  ≥160

1.00

0.84 (0.44–1.27)

1.04 (0.62–1.74)

1.12 (0.67–1.89)

0.45

 

 Cigarette smoking

     

0.13

  No

1.00

1.01 (0.64–1.61)

1.23 (0.78–1.96)

1.21 (0.76–1.91)

0.32

 

  Yes

1.00

4.68 (0.39–55.44)

13.41 (1.27–141.49)

6.87 (0.64–73.40)

0.10

 

 Alcohol consumption

     

0.26

  No

1.00

1.05 (0.67–1.66)

1.40 (0.89–2.20)

1.36 (0.87–2.13)

0.10

 

  Yes

1.00

—

—

—

NA

 

 Receiving immediate BP reduction

     

0.86

  No

1.00

1.15 (0.60–2.19)

1.73 (0.92–3.25)

1.39 (0.73–2.65)

0.19

 

  Yes

1.00

1.03 (0.54–1.98)

1.24 (0.65–2.37)

1.35 (0.72–2.53)

0.29

 
  1. NA: not available for limited sample size.
  2. In the multivariate models, confounding factors such as age, time from onset to hospitalization, current smoking, alcohol consumption, glucose, SBP, WBC, dyslipidemia, history of hypertension, history of coronary heart disease, history of diabetes mellitus, family history of stroke, current use of antihypertensive medications, baseline NIHSS score and randomized treatment were included unless the variable was used as a subgroup variable.
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