Figure 6
From: Distinct epigenomes in CD4+ T cells of newborns, middle-ages and centenarians
Age-specific differentially methylated regions (aDMRs) and related genes (aDMGs).
(A) Venn diagram of the distribution of genes corresponding to the blue, turquoise, royal blue and dark orange modules based on whether they possess CpG islands in promoters. (B) Circos representation of genome-wide DNA methylation levels in the NB, MA, and LL groups. From outer to inner, this graph displays chromosomal karyotypes; promoters; CpG islands; read distributions of the LL, MA, NB groups in 100-kb segments; and differential DMR distributions of NB vs MA, MA vs LL and NB vs LL. Green represents log2 ratios > 0, and red represents log2 ratios < 0. (C) aDMR distribution among different genomic sequences. (D) aDMG distribution according to the direction of the DNA methylation change, and GO enrichment analysis of these aDMGs between MA and NB individuals and between LL and MA individuals. (E) The patterns of change in promoter methylation of three aDMGs (BACH2, ATP5G and RFWD2) confirmed by BSP are consistent with the results from MeDIP-seq.
