Figure 2
From: Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4
Functional effects of KCNE3L and KCNE4L on hERG, and human Kv1.1.
(A) Exemplar current traces recorded from Xenopus oocytes expressing hERG alone (n = 25) or with KCNE3L (E3L; n = 18), or KCNE4L (E4L; n = 10). Insets: left, Voltage clamp protocol; right, scale bars. Zero current level indicated by dashed line. (B) Mean ± SEM peak current/voltage relationship for currents as in panel A; n values as in panel A. ***P < 1 × 10−8. NS, P > 0.05 (C) Exemplar current traces recorded from Xenopus oocytes expressing Kv1.1 alone (n = 26) or with KCNE3L (E3L; n = 19), or KCNE4L (E4L; n = 30). Insets: left, Voltage clamp protocol; right, scale bars. Zero current level indicated by dashed lines. (D) Mean ± SEM peak current/voltage relationship for currents as in panel C; n values as in panel C. ***P < 0.005. (E) Mean ± SEM normalized G/V relationship measured at beginning of tail pulse for currents as in panel C; n values as in panel C.
