Figure 6
From: Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4
Effects of KCNE3L and hKCNE4L on human Kv4.2/3 inactivation kinetics with/without KChIP2.
(A) Box plots showing individual and mean ± SEM values for τ of fast and slow components, and relative amplitude, of fast inactivation (double exponential fit) of Kv4.2 for currents recorded as in Fig. 4A; n = 6–12. *P < 0.05; **P < 0.01; by ANOVA followed by Tukey’s HSD test. Absence of brackets indicates P value versus all other groups. (B) Box plots showing individual and mean ± SEM values for τ of Kv4.2-KChIP2 inactivation (single exponential fit) for currents recorded as in Fig. 4C; n = 10–12. ***P < 0.0005. (C) Box plots showing individual and mean ± SEM values for τ of fast and slow components, and relative amplitude, of fast inactivation (double exponential fit) of Kv4.3 for currents recorded as in Fig. 5A; n = 6–11. *P < 0.05; **P < 0.01; by ANOVA followed by Tukey’s HSD test. Absence of brackets indicates P value versus all other groups. (D) Box plots showing individual and mean ± SEM values for τ of Kv4.3-KChIP2 inactivation (single exponential fit) for currents recorded as in Fig. 5C; n = 11–12. ***P < 1 × 10−7.
