Table 1 Estimates of the effect of genetically predicted birth weight (per 100 gram)¹² on ischemic heart disease (IHD) and myocardial infarction (MI)^13,14,15,16 obtained from Mendelian randomization using different data sources, different methodological approaches and different exclusions for pleiotropy.

Disease	Data source	Method	7 SNPs		5 SNPs^a		4 SNPs^b		2 SNPs^c,^d		10 SNPs^e
Disease	Data source	Method	Odds ratio	95% CI	Odds ratio	95% CI	Odds ratio	95% CI	Odds ratio	95% CI	Odds ratio	95% CI
IHD	CARDIoGRAMplusC4D 1000 Genomes based GWAS	IVW	0.96	0.93 to 0.99	0.97	0.94 to 1.01	0.96	0.93 to 1.00	0.98	0.93 to 1.03	0.96	0.93 to 0.99
	CARDIoGRAMplusC4D 1000 Genomes based GWAS	WM	0.96	0.92 to 1.00	0.96	0.92 to 1.01	0.96	0.92 to 1.01	N/A		0.96	0.92 to 1.00
	CARDIoGRAMplusC4D metabochip/CARDIoGRAM	IVW	0.99	0.95 to 1.03	1.02	0.97 to 1.06	1.00	0.96 to 1.05	1.06	0.97 to 1.16	0.99	0.96 to 1.03
	CARDIoGRAMplusC4D metabochip/CARDIoGRAM	WM	0.99	0.94 to 1.05	1.01	0.95 to 1.07	1.00	0.94 to 1.06	N/A		0.99	0.94 to 1.04
MI	CARDIoGRAMplusC4D 1000 Genomes based GWAS	IVW	0.96	0.92 to 0.99	0.98	0.94 to 1.02	0.97	0.93 to 1.01	0.97	0.92 to 1.03	0.96	0.93 to 0.99
MI	CARDIoGRAMplusC4D 1000 Genomes based GWAS	WM	0.95	0.91 to 1.00	0.96	0.91 to 1.00	0.96	0.91 to 1.00	N/A		0.95	0.91 to 0.99

^aExcluding SNPs related to height (rs724577(LCORL) and rs1042725 (HMGA2)).
^bExcluding SNPs related to height (rs724577(LCORL) and rs1042725 (HMGA2)) and blood pressure (rs1801253 (ADRB1)).
^cExcluding SNPs related to height (rs724577(LCORL) and rs1042725 (HMGA2)), blood pressure (rs1801253 (ADRB1)) and type 2 diabetes (rs6931514 (CDKAL1), rs9883204 (ADCY5)).
^dWeighted median method not available as one SNP contributed more than 50% of the information in the analysis.
^eIncluding SNPs which did not reach genome wide significance for birth weight but p value <10⁻⁵ (rs5415 (SLC2A4); rs5758511 (CENPM); and rs7780752 (CALCR)).
IVW: Inverse variance weighting method; WM: Weighted median method.

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