Table 3 Activation table of brain areas showing group differences during correct inhibition to lures; no differences were found between cirrhosis vs. no-cirrhosis and between amnestic group and unimpaired patients.

From: Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis

 

Cluster Index

Z-score

MNI (mm)

X

y

z

Amnestic/Non-amnestic >Unimpaired a

Cluster 2: 2252 voxels

 Central Opercular Cortex, L

2

3.50

−42

−22

20

 Postcentral Gyrus, L

2

3.20

−38

−24

40

 Insular Cortex, L

2

3.12

−36

−10

8

Cluster 1: 1199 voxels

 Postcentral Gyrus, R

1

3.16

34

−32

40

 Posterior Cingulate Gyrus, R

1

3.15

14

−36

42

 Superior Parietal Lobule, R

1

2.62

32

−40

58

Amnestic/Non-amnestic >Unimpaired b

Cluster 4: 5395 voxels

 Temporal Occipital Fusiform Cortex, R

4

3.63

38

−60

−10

 Occipital Pole, L

4

3.54

−22

−102

4

 Occipital Pole, R

4

3.40

32

−90

30

Cluster 3: 2670 voxels

 Central Opercular Cortex, L

3

3.70

−40

−20

22

 Insular Cortex, L

3

3.57

−38

−12

14

 Superior Parietal Lobule, L

3

3.16

−36

−42

58

 Postcentral Gyrus, L

3

3.02

−58

−14

46

Cluster 2: 1585 voxels

 Parietal Operculum Cortex, R

2

3.37

48

−24

30

 Postcentral Gyrus, R

2

3.35

56

−18

40

Cluster 1: 1029 voxels

 Precuneous Cortex, R

1

3.25

14

−36

44

 Precuneous Cortex, L

1

3.20

−10

−52

66

 Posterior Cingulate Gyrus, R

1

3.10

6

−36

46

 Superior Parietal Lobule, R

1

3.01

14

−50

64

 Lateral Occipital Cortex (Sup), R

1

2.91

24

−58

52

  1. aPresents the brain areas where the brain activation to correct inhibition to lures was significantly greater in the Amnestic/Non-Amnestic compared to Amnestic type groups on fMRI. bPresents the brain areas where the brain activation to correct inhibition to lures was significantly greater in the Amnestic/Non-Amnestic compared to the Unimpaired type group on fMRI. A ‘Cluster’ is a group of anatomically adjacent voxels found to be statistically significant after thresholding with z-threshold = 2.3 and p = 0.05. Z-score represents the magnitude of group differences in activation and Montreal Neurological Institute (MNI) coordinates (x, y and z axis) represent a standardized way of presenting the anatomical location of the peak Z-score on a normalized brain template.