Table 5 Group differences on brain volumetric analysis.

From: Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis

Brain volume region

Based on the disease

Brain volume region

Based on neuro-psychological performance

Non-cirrhotic

Cirrhosis

Unimpaired

Amnestic type

Amnestic+ Non-amnestic

White matter

6.87 ± 0.4

6.68 ± 0.5

White matter

6.99 ± 0.2**

6.34 ± 0.6†

6.88 ± 0.2

Gray matter

6.41 ± 0.5

6.34 ± 0.7

Gray matter

6.59 ± 0.5*

5.99 ± 0.6†

6.55 ± 0.4

Total brain

13.3 ± 0.7

13.0 ± 1.2

Total brain

13.6 ± 0.6**

12.4 ± 1.25†

13.4 ± 0.8

   

Hippocampus L

3.63 ± 0.4**

3.14 ± 0.5††

3.68 ± 0.3

   

Hippocampus R

3.80 ± 0.5

3.50 ± 0.4†

3.86 ± 0.3

   

Thalamus L

6.75 ± 0.5*

6.09 ± 0.7††

7.05 ± 0.6

   

Thalamus R

6.53 ± 0.5

6.18 ± 0.4††

6.81 ± 0.5

  1. *p < 0.05, **p < 0.01. Unimpaired vs. amnestic type; †p < 0.05, ††p < 0.01 amnestic vs. amnestic/non-amnestic type. For total brain volumes (white matter, gray matter and total brain) data are presented as x 10−5 mm3 while for local volumes (Hippocampus and Thalamus) data are presented as x 10−3 mm3. All subjects’ volumes are reported relative to a normalized skull size.
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